Hokamix can be given to puppies from the time of weaning as a preventative, to help keep them from getting problems. Puppies at weaning just need a little pinch. If they are being fed in those big, messy puppy pans, then start out with about 1/4 to 1/2 a scoop depending on the size, age and quantity of the puppies and gradually build them up as they get older. The nice thing about Hokamix and puppies is if you start them out young, they won't have the chance to build up those toxins like the older dogs have. Hokamix also works very well for pregnant bitches. Our customers who have used raspberry leaves for whelping stopped using them because they have gotten the same, or better, results with just the Hokamix. Remember, use Hokamix and they won't need anything else!!!